Decoding microRNAs in autism spectrum disorder
Jinyu Li, Xiaohui Xu, Jiane Liu, Sudan Zhang, Xiaohua Tan, Zhiqiang Li, Jian Zhang, Zheng Wang
Abstract
Autism spectrum disorder (ASD)-a congenital mental disorder accompanied by social dysfunction and stereotyped behaviors-has attracted a great deal of attention worldwide.A combination of genetic and environmental factors may determine the pathogenesis of ASD.Recent research of multiple ASD models indicates that microRNAs (miRNAs) play a central role at the onset and progression of ASD by repressing the translation of key mRNAs in neural development and functions.As such, miRNAs show great potential to serve as biomarkers for ASD diagnosis or prognosis and therapeutic targets for the treatment of ASD.In this review, we discuss the regulatory mechanisms by which miRNAs influence ASD phenotypes through various in vivo and in vitro models, including necropsy specimens, animal models, cellular models, and, in particular, induced pluripotent stem cells derived from patients with ASD.We then discuss the potential of miRNAbased therapeutic strategies for ASD currently being evaluated in preclinical studies.