Photocatalyzed Arylthiolation/Cyclization of 3‐(2‐(Ethynyl)phenyl)Quinazolinones with Disulfides towards Arylthiolated Quinolino[2,1‐<i>b</i>]Quinazolinones
Fan‐Lin Zeng, Jinwei Yuan, Junru Jiang, Meiyue Zhang, Sanyu Zhang, Yanli Yin, Liangru Yang, Yongmei Xiao, Lingbo Qu
Abstract
Abstract An approach to the synthesis of arylthiolated quinolino[2,1‐ b ]quinazolinones has been developed using unactivated alkynes containing quinazolinones and diaryldisulfides under visible light irradiation. The procedure entails a sequential radical arylthiolation and cyclization reaction. A possible radical mechanism has been investigated and proven as a single electron transfer (SET) process.
Topics & Concepts
ChemistryCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryComputational chemistryQuinazolinone synthesis and applicationsSulfur-Based Synthesis TechniquesPhenothiazines and Benzothiazines Synthesis and Activities