Rapidly progressive crescentic diabetic nephropathy: two case reports
Jade E. Schroers, Alexander M. Gilbert, Paul McKenzie, Paul Kirwan, Steven J. Chadban, Tracey Ying
Abstract
Crescents are not a well recognised feature of diabetic nephropathy. We present two cases of patients presenting with a rapid decline in renal function and subacute onset of nephrotic syndrome. Glomerulonephritis screening was negative, and renal biopsy revealed non-necrotising cellular crescents and typical features of late-stage diabetic nephropathy. We review the literature for diabetic nephropathy with crescents and explore possible underlying mechanisms.
Topics & Concepts
MedicineDiabetic nephropathyNephrotic syndromeNephropathyRenal biopsyGlomerulonephritisRenal functionDiabetes mellitusBiopsyRapidly progressive glomerulonephritisPathologyInternal medicineKidneyEndocrinologyRenal Diseases and GlomerulopathiesChronic Kidney Disease and DiabetesBiomedical Research and Pathophysiology