IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice
John S. Butterfield, Kentaro Yamada, Thaís B. Bertolini, Farooq Syed, Sandeep Kumar, Xin Li, Sreevani Arisa, Annie R. Piñeros, Alejandro Tapia, Christopher A. Rogers, Ning Li, Jyoti Rana, Moanaro Biswas, Cox Terhorst, Randal J. Kaufman, Ype P. de Jong, Roland W. Herzog
Topics & Concepts
Genetic enhancementTransgeneImmunologyBlockadeImmune systemCoagulationVectors in gene therapyCytokineBiologyAntibodyGene expressionFactor IXCD8MedicineCancer researchReceptorViral vectorGeneInternal medicineRecombinant DNAGeneticsVirus-based gene therapy researchCAR-T cell therapy researchHemophilia Treatment and Research