Distinct core glycan and <i>O</i> -glycoform utilization of SARS-CoV-2 Omicron variant Spike protein RBD revealed by top-down mass spectrometry
David S. Roberts, Morgan Mann, Brad H. Li, Donguk Kim, Allan R. Braiser, Song Jin, Ying Ge
Abstract
Top-down mass spectrometry reveals O -glycoform structural changes in the SARS-CoV-2 Omicron variant. Resolving the mutations and post-translational alterations can inform strategies for designing variant-directed diagnostics and therapeutics.
Topics & Concepts
GlycanSpike (software development)ChemistrySpike ProteinMass spectrometryComputational biologyCoronavirus disease 2019 (COVID-19)BiologyChromatographyBiochemistryGlycoproteinComputer scienceMedicineDiseaseInfectious disease (medical specialty)Software engineeringPathologySARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingAnimal Virus Infections Studies