The robust NMR toolbox for metabolomics
Kousik Chandra, Samah Al-Harthi, Fatimah Almulhim, Abdul‐Hamid Emwas, Łukasz Jaremko, Mariusz Jaremko
Abstract
Here, we implemented and validated a suite of selective and non-selective CPMG-filtered 1D and 2D TOCSY/HSQC experiments for metabolomics research. They facilitated the unambiguous identification of metabolites embedded in broad lipid and protein signals. The 2D spectra improved non-targeted analysis by removing the background broad signals of macromolecules.
Topics & Concepts
ToolboxMetabolomicsComputer scienceComputational biologyChemistryBiologyProgramming languageChromatographyMetabolomics and Mass Spectrometry StudiesTraditional Chinese Medicine StudiesNMR spectroscopy and applications