Spherical agglomeration of high melting point drugs in water at low temperature by developing a two-step oiling-out mechanism and the design strategy
Yanbo Liu, Yiming Ma, Changyou Yu, Ye Gao, Kangli Li, Tong Li, Mingyang Chen, Junbo Gong
Abstract
An efficient spherical agglomeration technology for high melting point drugs was developed by designing a two-step oiling-out (TSOO) mechanism, and spherical particles of 13 high melting point drugs were successfully prepared in water.
Topics & Concepts
Economies of agglomerationMelting pointMechanism (biology)Melting temperaturePoint (geometry)Materials scienceNanotechnologyChemical engineeringChemistryComposite materialGeometryPhysicsMathematicsEngineeringQuantum mechanicsCrystallization and Solubility StudiesInnovative Microfluidic and Catalytic Techniques InnovationDrug Solubulity and Delivery Systems