SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression
Ye Jin Kim, Jonghwa Jin, Dongho Kim, Daehoon Kim, You Mie Lee, Jun‐Kyu Byun, Yeon‐Kyung Choi, Keun‐Gyu Park
Topics & Concepts
Macrophage polarizationChemistrymTORC1Inflammatory bowel diseaseProtein kinase BPI3K/AKT/mTOR pathwayMacrophageGlycolysisLipopolysaccharideCancer researchProinflammatory cytokineColitisInflammationCell biologyPharmacologySignal transductionImmunologyBiochemistryBiologyMedicineIn vitroInternal medicineEnzymeDiseaseImmune cells in cancerInflammatory Bowel DiseaseNeutrophil, Myeloperoxidase and Oxidative Mechanisms