Palladium-Catalyzed Asymmetric Carbonylation of Alkynes to Axially Chiral Carbothioate Esters
Yao Wang, Yang Yuan, Ting Yang, Yong‐Gui Zhou, Xiao‐Feng Wu
Abstract
High Resolution Image Download MS PowerPoint Slide Herein, we report a novel palladium-catalyzed asymmetric hydrothioesterification of alkynes under mild conditions, enabling the precise construction of axially chiral carboxylic thioester derivatives with excellent yields, regioselectivity, E / Z selectivity, and enantioselectivity. Disulfides and thiosulfonates were applicable, as well.
Topics & Concepts
ChemistryAxial symmetryCarbonylationThioesterAxial chiralityCarboxylic acidChirality (physics)CatalysisPolymer chemistryCombinatorial chemistryOrganic chemistryMedicinal chemistryDimerComputational chemistryAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis