Inventing Novel Protein Folds
Nobuyasu Koga, Rie Koga
Abstract
• Estimation of the number of novel αβ-folds through de novo protein design. • Principles for protein design. • Prospects for design of functional proteins with novel folds. The vastness of unexplored protein fold universe remains a significant question. Through systematic de novo design of proteins with novel αβ-folds, we demonstrated that nature has only explored a tiny portion of the possible folds. Numerous possible protein folds are still untouched by nature. This review outlines this study and discusses the prospects for design of functional proteins with novel folds.
Topics & Concepts
Fold (higher-order function)Computational biologyProtein evolutionProtein designBiologyProtein structureEvolutionary biologyComputer scienceGeneticsBiochemistryGeneProgramming languageProtein Structure and DynamicsRNA and protein synthesis mechanismsGlycosylation and Glycoproteins Research