CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function
Karsen E. Shoger, Neha Cheemalavagu, Yuqi Cao, Brandon A. Michalides, Virendra K. Chaudhri, Jonathan Cohen, Harinder Singh, Rachel A. Gottschalk
Abstract
The protein CISH fine-tunes homeostatic lung cytokine signaling to maintain alveolar macrophage identity and function.
Topics & Concepts
CytokineCell biologyBiologySuppressor of cytokine signaling 1STAT5Signal transductionTranscription factorCancer researchImmunologyGeneBiochemistrySuppressorNeonatal Respiratory Health ResearchImmune cells in cancerEpigenetics and DNA Methylation