Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling
Jesse D. Kirkpatrick, Andrew Warren, Ava P. Soleimany, Peter M.K. Westcott, Justin C. Voog, Carmen Martin-Alonso, Heather E. Fleming, Tuomas Tammela, Tyler Jacks, Sangeeta N. Bhatia
Abstract
-mutant lung adenocarcinoma mouse model confirmed the role of metalloproteases in lung cancer and enabled accurate detection of localized disease, with 100% specificity and 81% sensitivity. Furthermore, this approach generalized to an alternative autochthonous model of lung adenocarcinoma, where it detected cancer with 100% specificity and 95% sensitivity and was not confounded by lipopolysaccharide-driven lung inflammation. These results encourage the clinical development of activity-based nanosensors for the detection of lung cancer.
Topics & Concepts
Lung cancerProteasesMedicineKRASNanosensorLungCancer researchCancerAdenocarcinomaPathologyBiologyColorectal cancerInternal medicineMaterials scienceEnzymeNanotechnologyBiochemistryAdvanced biosensing and bioanalysis techniquesNanoplatforms for cancer theranosticsBiosensors and Analytical Detection