Targeting Superoxide Dismutase Confers Enhanced Reactive Oxygen Species-Mediated Eradication of Polymyxin B-Induced Acinetobacter baumannii Persisters
Vineet Dubey, Rinki Gupta, Ranjana Pathania
Abstract
Bacterial persisters represent noninheritable drug-tolerant populations that are linked to recalcitrance of infections in health care settings. The rise of antibiotic resistance and the depletion of new antibiotics in the drug discovery pipeline have made the task of persister eradication more daunting.
Topics & Concepts
Acinetobacter baumanniiPolymyxinMicrobiologyAntibioticsPolymyxin BSuperoxide dismutaseBiologyMultidrug toleranceReactive oxygen speciesDrug resistanceAcinetobacterBacteriaPseudomonas aeruginosaBiofilmOxidative stressBiochemistryGeneticsAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsBacterial biofilms and quorum sensing