Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid
Dongsheng Ji, Jiahui Zhang, Jihai Liang, Zhi‐Shu Huang, Bing Shu, Ding Li
Abstract
-induced apoptosis. Further studies showed that B14 also exhibited good ability to cross the blood-brain barrier (BBB), which significantly improved learning memory and cognitive deficits, reduced brain Aβ plaques, alleviated inflammation and restored oxidative stress markers in APP/PS1 mice. Our findings provide an innovative strategy of dual targeting BCL-2 promoter i-motif for transcriptional regulation and Aβ aggregation synergistically for mitigating AD pathologies. B14 represents a promising multi-target lead compound with a good potential for further development for AD treatment.
Topics & Concepts
Oxidative stressApoptosisAlzheimer's diseaseGeneBiologyDiseaseAmyloid precursor proteinCell biologyAmyloid (mycology)NeurodegenerationCancer researchNeuroscienceGeneticsMedicinePathologyBiochemistryBotanyAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesNuclear Receptors and Signaling