Mifepristone (RU486) inhibits dietary lipid digestion by antagonizing the role of glucocorticoid receptor on lipase transcription
Peng Ma, Yao Zhang, Qiying Liang, Youjie Yin, Saifei Wang, Ruolei Han, Chunyu Huo, Hansong Deng
Abstract
is a direct transcriptional target of GR in pancreas tissues. Glucocorticoid levels in mice fed a high fat diet (HFD) are significantly lower than those fed on a conventional diet, and RU486 administration inhibits HFD-induced obesity both in mice and flies. Our findings identified a novel mechanism of RU486 functions as a GR antagonist systematically regulating lipid metabolism, providing new insight on the role of Glucocorticoid/GR in Cushing disease, diabetes, and other related metabolic syndromes.
Topics & Concepts
MifepristoneGlucocorticoidAntiglucocorticoidEndocrinologyInternal medicineLipid metabolismGlucocorticoid receptorDigestion (alchemy)PeroxisomeLipid dropletBiologyLipaseReceptorChemistryEnzymeBiochemistryMedicineGeneticsChromatographyPregnancyAdipose Tissue and MetabolismRegulation of Appetite and ObesityPharmacology and Obesity Treatment