Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities
Yu Zhang, Hao Yang, Fang‐Ting Wang, Xing Peng, Hai‐Yang Liu, Qingjiang Li, Lin‐Kun An
Topics & Concepts
ChemistryDU145TopoisomeraseCytotoxicityEnzyme inhibitorEnantioselective synthesisEtoposideDNAEnzymeBiochemistryStereochemistryCancer cellIn vitroCancerBiologyChemotherapyCatalysisLNCaPGeneticsCancer therapeutics and mechanismsSynthesis and Biological ActivitySynthesis and Biological Evaluation