Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways
Junsheng Tian, Z. Wu, Dan Wu, Chen Yang, Yao Gao, Dong-lan Yan, Xuemei Qin
Topics & Concepts
PI3K/AKT/mTOR pathwayAntidepressantProtein kinase BDownregulation and upregulationPharmacologyAnimal models of depressionMechanism (biology)HippocampusSignal transductionNeuroscienceMedicineChemistryPsychologyBiologyCell biologyGeneBiochemistryPhilosophyEpistemologyTryptophan and brain disordersTreatment of Major DepressionMental Health Research Topics