Pd-catalyzed enantioselective intramolecular Heck reaction to access disubstituted dihydroisoquinolinone with a terminal olefin
Sanliang Li, Qiaoyu Chen, Zhan‐Ming Zhang, Junliang Zhang
Abstract
A first palladium-catalyzed asymmetric intramolecular Heck reaction for the construction 3,4-dihydro-1-(2H)-isoquinolinone containing the quaternary carbon chiral center has been developed. The salient features of this reaction include high efficiency, high enantioselectivity, the novel chiral ligand and diverse transformations.
Topics & Concepts
Enantioselective synthesisIntramolecular forceOlefin fiberCatalysisHeck reactionChemistryQuaternary carbonPalladiumLigand (biochemistry)Combinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryReceptorBiochemistryCatalytic Cross-Coupling ReactionsChemical synthesis and alkaloidsCatalytic C–H Functionalization Methods