Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates <i>MYCN</i> -amplified neuroblastoma growth
Yu-Feng Guo, Jiang‐Jie Duan, Jun Wang, Lin Li, Di Wang, Xun-Zhou Liu, Jing Yang, Huarong Zhang, Jing Lv, Yongjun Yang, Zeyu Yang, Jiao Cai, Xuemei Liao, Tao Tang, Tingting Huang, Feng Wu, Xianyan Yang, Qian Wen, Xiu‐Wu Bian, Shi‐Cang Yu
Abstract
The ALDH18A1-MYCN positive feedback loop points to a promising therapeutic target in MYCN -amplified neuroblastoma.
Topics & Concepts
NeuroblastomaCancer researchMedicineBiologyInternal medicineGeneticsCell cultureNeuroblastoma Research and TreatmentsCancer, Hypoxia, and MetabolismCancer therapeutics and mechanisms