Helicobacter pylori–Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive Defense
Fangyuan Mao, Yi-pin Lv, Chuan-jie Hao, Yong‐sheng Teng, Yugang Liu, Ping Cheng, Shiming Yang, Weisan Chen, Tao Liu, Quanming Zou, Rui Xie, Jingyu Xu, Yuan Zhuang
Abstract
BACKGROUND & AIMS: Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. METHODS: T cells were isolated, stimulated and/or cultured for Rev-erbα function assays. RESULTS: myeloid cells by CCL21-CCR7-dependent migration and, as a direct consequence, reduced bacterial clearing capacity of H pylori-specific Th1 cell response. CONCLUSIONS: Overall, this study identifies a model involving Rev-erbα, which collectively ensures gastric bacterial persistence by suppressing host gene expression required for local innate and adaptive defense against H pylori.