Micelle-guided Morita–Baylis–Hillman reaction of ketones in water
Mohmad Muzafar Wani, Aijaz Ahmad Dar, Bilal A. Bhat
Abstract
A novel Morita-Baylis-Hillman reaction employing electron-deficient alkenes like acrylonitrile with a wide range of aryl and aliphatic ketones using cooperative catalysis in micellar media has been delineated. This transformation executed in water under mild reaction conditions in a confined environment of micelles is aligned to the ideas of sustainable and green chemistry. The site of the reaction was established by incisive proton NMR studies in the palisade region of the micellar assembly. This study is expected to encourage the use of micellar catalysis for energetically less favorable chemical reactions.
Topics & Concepts
Morita therapyBaylis–Hillman reactionMicelleCatalysisChemistryOrganic chemistryMedicinal chemistryPsychologyAqueous solutionPsychoanalysisAsymmetric Synthesis and CatalysisChemical Synthesis and ReactionsChemical Synthesis and Analysis