Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway
Shisheng Wang, Qiaoli Zhang, Peng Chu, Lingqi Kong, Guangzhe Li, Yueqing Li, Yang Li, Weijie Zhao, Xiuhan Guo, Zeyao Tang
Topics & Concepts
PI3K/AKT/mTOR pathwayChemistryHeLaOleanolic acidProtein kinase BApoptosisPharmacophoreMoietyIn vitroStereochemistryBiochemistryAlternative medicineMedicinePathologyNatural product bioactivities and synthesisBioactive Compounds and Antitumor AgentsPhytochemical compounds biological activities