Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles
Peer Erfle, Juliane Riewe, Songtao Cai, Heike Bunjes, Andreas Dietzel
Abstract
and organic phase mixing ratios of up to 20% resulted in particle sizes ranging from 42 nm to 166 nm with polydispersity indices from 0.04 to 0.11, indicating very narrowly distributed, and in most cases even monodisperse, nanoparticles. The occurrence of fouling can be completely suppressed with this new type of mixing elements, as long as Dean vortices are prevented. Moreover, this parameter range in the horseshoe lamination mixer provided a stable and continuous process, which enables a scalable production.
Topics & Concepts
DispersityNanoparticleHorseshoe (symbol)LaminationMaterials scienceChemical engineeringTransformation (genetics)PrecipitationNanotechnologyChemistryEngineeringComputer sciencePhysicsMeteorologyGeneLayer (electronics)Programming languageBiochemistryInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Capillary Electrophoresis ApplicationsElectrohydrodynamics and Fluid Dynamics