Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity
Li Lin, Yuanyuan Chen, Qiang Li, Guang Xu, Kaixin Ding, Lutong Ren, Wei Shi, Yan Wang, Zhiyong Li, Wenzhang Dai, Ziying Wei, Yan Yang, Zhaofang Bai, Xiaohe Xiao
Topics & Concepts
InflammasomeSophora flavescensPharmacologyWestern blotBiochemistryAIM2Molecular biologyChemistryBiologyReceptorMatrineChromatographyGeneInflammasome and immune disordersHops Chemistry and ApplicationsDrug-Induced Hepatotoxicity and Protection