Self-driving armored CAR-T cells overcome a suppressive milieu and eradicate CD19+ Raji lymphoma in preclinical models
Brian Webster, Ying Xiong, Peirong Hu, Darong Wu, Leah Alabanza, Rimas J. Orentas, Boro Dropulić, Dina Schneider
Topics & Concepts
BiologyDownregulation and upregulationCD19AntigenTranscription factorCancer researchMolecular biologyImmunologyCell biologyGeneBiochemistryCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy research