A high-throughput 3D bioprinted cancer cell migration and invasion model with versatile and broad biological applicability
MoonSun Jung, Joanna N. Skhinas, Eric Y. Du, M. A. Kristine Tolentino, Robert H. Utama, Martin Engel, Alexander Volkerling, Andrew Sexton, Aidan P. O’Mahony, Julio Ribeiro, J. Justin Gooding, Maria Kavallaris
Abstract
and real-time measurement of cell movement, (iii) detailed molecular analysis for the study of mechanisms underlying cell migration and invasion, and (iv) the identification of novel therapeutic options. This work demonstrates that this HTP 3D bioprinted cell migration platform has broad applications across quantitative cell and cancer biology as well as drug screening.
Topics & Concepts
Cancer cellCell migration3D cell cultureCellExtracellular matrixNanotechnologyChemistryComputer scienceCancerCell biologyBiologyMaterials scienceBiochemistryGenetics3D Printing in Biomedical ResearchCellular Mechanics and InteractionsCancer Cells and Metastasis