Intestinal mucin is a chaperone of multivalent copper
Nava Reznik, Annastassia D. Gallo, Katherine W. Rush, Gabriel Javitt, Yael Fridmann‐Sirkis, Tal Ilani, Noa A. Nairner, Simon Fishilevich, David Gokhman, Kelly N. Chacón, Katherine J. Franz, Deborah Fass
Abstract
, the intestinal mucin, MUC2, prevents copper toxicity by blocking futile redox cycling and the squandering of dietary antioxidants, while nevertheless permitting uptake of this important trace metal into cells. These findings emphasize the value of molecular structure in advancing mucosal biology, while introducing mucins, produced in massive quantities to guard extensive mucosal surfaces, as extracellular copper chaperones.
Topics & Concepts
BiologyChaperone (clinical)MucinCopperMicrobiologyCell biologyBiochemistryPathologyOrganic chemistryChemistryMedicineTrace Elements in HealthDrug Transport and Resistance MechanismsHelicobacter pylori-related gastroenterology studies