Synthesis of 1<i>H</i>-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
Areum Park, Kyu‐Sung Jeong, Hyuk Lee, Hyunwoo Kim
Abstract
-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.
Topics & Concepts
AminationIntramolecular forceOxidative phosphorylationChemistryCombinatorial chemistryElectron transferOrganic chemistryCatalysisBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques