The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis
Jingwei Jin, Hao He, Xinyue Zhang, Rihui Wu, Li‐She Gan, Dongli Li, Yu‐Jing Lu, Panpan Wu, Wing‐Leung Wong, Kun Zhang
Topics & Concepts
Oleanolic acidChemistryPharmacologyIn vivoInflammationAnti-inflammatoryChemokineIn vitroProinflammatory cytokinePI3K/AKT/mTOR pathwayBiochemistryTumor necrosis factor alphaNatural productSignal transductionImmunologyReceptorBiologyMedicineBiotechnologyPathologyAlternative medicineNatural product bioactivities and synthesisBioactive Compounds and Antitumor AgentsNF-κB Signaling Pathways