Facile access to benzofuran-fused tetrahydropyridines <i>via</i> catalytic asymmetric [4 + 2] cycloaddition of aurone-derived 1-azadienes with 3-vinylindoles
Wai Lean Koay, Guang‐Jian Mei, Yixin Lü
Abstract
A highly enantioselective [4 + 2] cycloaddition reaction of 1-azadienes with 3-vinylindoles, catalyzed by chiral phosphoric acid has been developed to furnish a range of benzofuran-fused tetrahydropyridines with three contiguous stereogenic centers.
Topics & Concepts
StereocenterChemistryCycloadditionBenzofuranEnantioselective synthesisPhosphoric acidCatalysisCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsAsymmetric Synthesis and Catalysis