Differences in New Variant of Concern Replication at Physiological Temperatures In Vitro
Charles B. Stauft, Kotou Sangare, Tony T. Wang
Abstract
Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and infectivity in vitro. Ancestral and Delta SARS-CoV-2 variant exhibit reduced virus production and replication at 34°C compared to 37°C while Omicron replication is balanced between temperatures.
Topics & Concepts
Replication (statistics)InfectivityBiologyIn vitroVirusVirologyViral replicationGeneticsSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing