Coordinating Proliferation, Polarity, and Cell Fate in the Drosophila Female Germline
Taylor D. Hinnant, Julie A. Merkle, Elizabeth T. Ables
Abstract
that advance our understanding of how early germ cells balance mitotic exit with meiotic initiation. We discuss cell cycle control and establishment of cell polarity as major themes in oocyte specification. We also highlight a germline-specific organelle, the fusome, as integral to the coordination of cell division, cell polarity, and cell fate in ovarian germ cells. Finally, we discuss how the molecular controls of the cell cycle might be integrated with cell polarity and cell fate to maintain oocyte production.
Topics & Concepts
BiologyOocyteCell biologyGermlineCell fate determinationGerm cellGameteMeiosisDrosophila melanogasterMitosisCell divisionGeneticsCell cycleAsymmetric cell divisionCellEmbryoGeneSpermTranscription factorGenetics, Aging, and Longevity in Model OrganismsDevelopmental Biology and Gene RegulationReproductive Biology and Fertility