METTL3 regulates thyroid cancer differentiation and chemosensitivity by modulating PAX8
Kang Ning, Zewei Zhao, Zhongyu Wang, Junya Ning, Huijuan Wang, Wei Zhang, Xianhui Ruan, Ming Gao, Xiangqian Zheng
Abstract
I) administration. Overall, the METTL3/PAX8/YTHDC1 axis has been revealed to play a pivotal role in repressing tumour occurrence, and is antagonized by miR-493-5p.
Topics & Concepts
PAX8Thyroid cancerCancer researchGene silencingAnaplastic thyroid cancerCancerThyroid carcinomaMedicinemicroRNAIn vivoThyroidInternal medicineMethyltransferaseBiologyGeneMethylationTranscription factorGeneticsRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research