De novo nucleotide biosynthetic pathway and cancer
Jie Chen, Siqi Yang, Yingge Li, Ziwen Xu, Pingfeng Zhang, Qibin Song, Yi Yao, Huadong Pei
Abstract
De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation. Thus, the dysregulation of the de novo nucleotide biosynthetic pathway contributes to the development of many human diseases, such as cancer. It has been shown that many enzymes in this pathway are overactivated in different cancers. In this review, we summarize and update the current knowledge on the de novo nucleotide biosynthetic pathway, regulatory mechanisms, its role in tumorigenesis, and potential targeting opportunities.
Topics & Concepts
NucleotideBiologyDe novo synthesisPurineCarcinogenesisPyrimidine metabolismNucleotide salvageMetabolic pathwayGeneticsEnzymeBiochemistryComputational biologyCancerGeneBiochemical and Molecular ResearchRNA modifications and cancerEpigenetics and DNA Methylation