Biosynthesis of retinyl esters in <i>Yarrowia lipolytica</i> through metabolic engineering and fermentation condition optimization
Jin Zhang, Lingxuan Sun, Wen‐Li Yang, Huangwei Xu, Juzheng Sheng, Mengmeng Liu, Qingsheng Qi, Jin Hou
Abstract
Through metabolic engineering and fermentation optimization, Yarrowia lipolytica was engineered to produce 5.89 g L −1 retinol and 8.18 g L −1 retinyl esters. Our work lays the foundation for the sustainable bioproduction of retinoids.
Topics & Concepts
YarrowiaMetabolic engineeringFermentationChemistryBiochemistryBiosynthesisYeastOrganic chemistryEnzymeMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and ImmobilizationBiofuel production and bioconversion