The activation of antiviral RNA interference not only exists in neural progenitor cells but also in somatic cells in mammals
Yuqiang Zhang, Zhe Li, Zhi Ye, Yan Xu, Binbin Wang, Congcong Wang, Yunpeng Dai, Jinfeng Lü, Boxun Lu, Wanju Zhang, Yang Li
Abstract
upon infection in both central neuron system (CNS) and muscle tissues. In addition, our findings demonstrate the production of canonical vsiRNAs in murine CNS upon antiviral RNAi activation by Sindbis virus (SINV), suggesting the possibility of antiviral immune strategy applied by mammals in the CNS.
Topics & Concepts
Sindbis virusRNA interferenceBiologyVirologyCell biologyRNAEx vivoProgenitor cellVirusNeural stem cellIn vivoStem cellGeneticsGeneinterferon and immune responsesRNA Interference and Gene DeliveryExtracellular vesicles in disease