Prolonged release of an antimicrobial peptide GL13K-loaded thermosensitive hydrogel on a titanium surface improves its antibacterial and anti-inflammatory properties
Lin Zhou, Yifeng Xing, Yanjin Ou, Jiamin Ding, Han Yu, Lin Dong, Jiang Chen
Abstract
immunofluorescence staining and flow cytometry. Thus, the thermosensitive PLGA-PEG-PLGA hydrogel release system carrying the antimicrobial peptide GL13K on a titanium surface exhibited antibacterial and anti-inflammatory properties and promoted macrophage polarization from the M1 to M2 phenotype, which may help create a favourable niche for bone formation under infective condition.
Topics & Concepts
TitaniumChemistryAntimicrobialMacrophage polarizationPorphyromonas gingivalisSurface modificationPLGAPeptideMicrobiologyBiophysicsMaterials scienceMacrophageIn vitroBiochemistryPeriodontitisMedicineDentistryBiologyOrganic chemistryPhysical chemistryAntimicrobial Peptides and ActivitiesBone Tissue Engineering MaterialsOral microbiology and periodontitis research