Computational redesign of taxane-10β-hydroxylase for de novo biosynthesis of a key paclitaxel intermediate
Meifang Zhang, Wenliang Xie, Cheng Chen, Chun‐Xiu Li, Jian‐He Xu
Topics & Concepts
PaclitaxelTaxaneKey (lock)BiosynthesisChemistryBiochemistryComputational biologyEnzymeBiologyGeneticsEcologyCancerBreast cancerCancer Treatment and PharmacologyMicrobial Natural Products and BiosynthesisPlant biochemistry and biosynthesis