Acceptor-mediated regioselective enzyme catalyzed sialylation: chemoenzymatic synthesis of GAA-7 ganglioside glycan
Hsin‐Kai Tseng, Yung‐Yu Su, Ting-Wei Chang, Hsin-Chien Liu, Pei‐Jhen Li, Pei‐Yun Chiang, Chun‐Cheng Lin
Abstract
The glycan of GAA-7 was facilely synthesized by enzymatic glycosylation through changing the nonreducing acceptor into GalNH<sub>2</sub> or GalAz to successfully switch the regioselectivity of PmST1.
Topics & Concepts
RegioselectivityGlycanGlycosylationChemistryAcceptorEnzymeCatalysisStereochemistryCombinatorial chemistryBiochemistryGlycoproteinPhysicsCondensed matter physicsGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisEnzyme Production and Characterization