δ-opioid receptor activation protects against Parkinson’s disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy
Yuan Xu, Feng Zhi, Jiahao Mao, Ya Peng, Nan Shao, Gianfranco Balboni, Yilin Yang, Ying Xia
Abstract
in terms of the regulation of mitophagy with hypoxia-induced mitophagy being independent from DOR-PINK1 signaling. Taken together, our novel data suggest that DOR activation is neuroprotective against parkinsonian injury by specifically promoting mitophagy in a PINK1-dependent pathway and thus attenuating mitochondrial damage.
Topics & Concepts
PINK1MitophagyParkinMitochondrionNeuroprotectionCell biologyGene knockdownChemistryPharmacologyAutophagyBiologyParkinson's diseaseApoptosisMedicineBiochemistryInternal medicineDiseaseAutophagy in Disease and TherapyCannabis and Cannabinoid ResearchParkinson's Disease Mechanisms and Treatments