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Design, synthesis and<i>in vitro</i>antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors

Zohor Mohammad Mahdi Alzhrani, Mohammad Mahboob Alam, Thikryat Neamatallah, Syed Nazreen

2020Journal of Enzyme Inhibition and Medicinal Chemistry66 citationsDOIOpen Access PDF

Abstract

has the potential to be developed as TS inhibitors.

Topics & Concepts

Thymidylate synthaseChemistryOxadiazoleCytotoxicityIn vitroIC50Cell cultureEnzymeStereochemistryDocking (animal)BiochemistryBiologyMedicineOrganic chemistryFluorouracilGeneticsChemotherapyNursingBiochemical and Molecular ResearchColorectal Cancer Treatments and StudiesSynthesis and biological activity
Design, synthesis and<i>in vitro</i>antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors | Litcius