Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues
B. Somsen, Fenna W. B. Craenmehr, Wei-Hong W. Liu, Auke A. Koops, Marloes Pennings, Emira J. Visser, Christian Ottmann, Peter J. Cossar, Luc Brunsveld
Abstract
The functional mapping of a 14-3-3 protein complex, by means of peptide truncations and point mutations, as an approach to identify critical hotspots regions for 14-3-3 molecular glue drug design.
Topics & Concepts
Computational biologyComputer scienceBiology14-3-3 protein interactionsUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors