Electronic Cigarette Solvents, JUUL E-Liquids, and Biomarkers of Exposure: In Vivo Evidence for Acrolein and Glycidol in E-Cig-Derived Aerosols
Pawel Lorkiewicz, Rachel J. Keith, Jordan Lynch, Lexiao Jin, Whitney S. Theis, Tatiana Krivokhizhina, Daniel W. Riggs, Aruni Bhatnagar, Sanjay Srivastava, Daniel J. Conklin
Abstract
-23HPMA. Our stable isotope tracing experiments provide further evidence that thermal decomposition of vegetable glycerin in the e-cigarette solvent leads to generation of acrolein and glycidol. This suggests that the adverse health effects of e-cigarettes may be attributable in part to these reactive compounds formed through the process of aerosolizing nicotine. Our findings also support the notion that 23HPMA, but not 3HPMA, may be a relatively specific biomarker of e-cigarette use.
Topics & Concepts
AcroleinChemistryGlycidolIn vivoUrinary systemEnvironmental chemistryFood scienceChromatographyBiochemistryInternal medicineMedicineBiologyCatalysisBiotechnologySmoking Behavior and CessationAdipose Tissue and MetabolismPhytochemicals and Antioxidant Activities