Vicinal stereocenters <i>via</i> asymmetric allylic alkylation and Cope rearrangement: a straightforward route to functionally and stereochemically rich heterocycles
Aleksandra Nilova, Michael D. Mannchen, Abdias N. Noel, Evgeniya Semenova, Alexander J. Grenning
Abstract
Functionally and stereochemically rich saturated heterocycles are accessed stereoselectively from abundant resources. This work showcases the sequenced value of asymmetric allylic alkylation, Cope rearrangement, and Hayashi–Lear oxidative amidation.
Topics & Concepts
StereocenterMoietyAllylic rearrangementVicinalAlkylationStereochemistryStereoselectivityChemistryCope rearrangementTsuji–Trost reactionEnantioselective synthesisCombinatorial chemistryOrganic chemistryCatalysisAsymmetric Synthesis and CatalysisAdvanced Synthetic Organic ChemistrySynthetic Organic Chemistry Methods