Ultrasmall PtAu<sub>2</sub> nanoclusters activate endogenous anti-inflammatory and anti-oxidative systems to prevent inflammatory osteolysis
Xuzhuo Chen, Xiankun Cao, Dasheng Zheng, Chang Li, Yan Chen, Keyu Kong, Weifeng Xu, Bin Shi, Xinwei Chen, Feng‐Rong Dai, Shanyong Zhang
Abstract
Through the rational design of novel heterometallic nanoclusters that activate the endogenous anti-inflammatory system, this study provides new insights into the development of multifunctional molecular therapeutic agents for inflammatory osteolysis and other inflammatory diseases.
Topics & Concepts
OsteolysisIn vivoChemistryNanoclustersKEAP1Nitric oxideInflammationOxidative stressIn vitroCancer researchCell biologyImmunologyBiochemistryMedicineTranscription factorBiologyOrganic chemistryBiotechnologyGeneSurgeryNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisTrace Elements in Health