Dehydration of primary amides to nitriles in water. Late-stage functionalization and 1-pot multistep chemoenzymatic processes under micellar catalysis conditions
Alex B. Wood, Joseph R. A. Kincaid, Bruce H. Lipshutz
Abstract
Palladium-catalyzed dehydration of primary amides to the corresponding nitriles can be performed in aqueous micelles, without need of significant volumes of organic co-solvent.
Topics & Concepts
ChemistryCatalysisDehydrationPrimary (astronomy)Surface modificationAqueous solutionMicelleOrganic chemistrySolventAmideCombinatorial chemistryBiochemistryPhysicsPhysical chemistryAstronomyChemical Synthesis and AnalysisChemical Synthesis and ReactionsMulticomponent Synthesis of Heterocycles