Litcius/Paper detail

ChEMBL: towards direct deposition of bioassay data

David Méndez, Anna Gaulton, A. Patrícia Bento, Jon Chambers, Marleen De Veij, Eloy Félix, María Paula Magariños, Juan F Mosquera, Prudence Mutowo, Michał Nowotka, María Gordillo‐Marañón, Fiona Hunter, Laura Junco, Grace Mugumbate, M. Rodríguez-López, Francis Atkinson, Nicolas Bosc, Chris J. Radoux, Aldo Segura‐Cabrera, Anne Hersey, Andrew R. Leach

2018Nucleic Acids Research2,429 citationsDOIOpen Access PDF

Abstract

ChEMBL is a large, open-access bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012, 2014 and 2017 Nucleic Acids Research Database Issues. In the last two years, several important improvements have been made to the database and are described here. These include more robust capture and representation of assay details; a new data deposition system, allowing updating of data sets and deposition of supplementary data; and a completely redesigned web interface, with enhanced search and filtering capabilities.

Topics & Concepts

chEMBLBiologyInterface (matter)BioassayDatabaseComputer scienceDeposition (geology)Relational databaseComputational biologyBioinformaticsDrug discoveryGibbs isothermBiochemistrySedimentGeneticsPaleontologyPulmonary surfactantComputational Drug Discovery MethodsMetabolomics and Mass Spectrometry StudiesBioinformatics and Genomic Networks