Enhanced ectopic bone formation by strontium-substituted calcium phosphate ceramics through regulation of osteoclastogenesis and osteoblastogenesis
Fuying Chen, Luoqiang Tian, Ximing Pu, Qin Zeng, Yumei Xiao, Xuening Chen, Xingdong Zhang
Abstract
. These findings may help in the design and fabrication of smart bone substitutes with the desired potential for bone regeneration through modulating both osteoclastic resorption and osteoblastic synthesis.
Topics & Concepts
OsteoclastChemistryCell biologyOsteoblastMesenchymal stem cellEctopic expressionMAPK/ERK pathwayIn vivoSignal transductionIn vitroBiologyBiochemistryGeneBiotechnologyBone Tissue Engineering MaterialsBone Metabolism and DiseasesBone and Dental Protein Studies