NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline
Graziano Di Carmine, Luke Forster, Simeng Wang, Christopher M. A. Parlett, Armando Carlone, Carmine D’Agostino
Abstract
The behaviour of solvents in solid-supported proline organocatalysts is explored using NMR relaxation measurements coupled with reaction screening. Solvents with a lower affinity for the solid surface lead to a higher reactivity.
Topics & Concepts
Aldol reactionProlineReactivity (psychology)ChemistrySolventRelaxation (psychology)Organic chemistryCatalysisAmino acidPathologyBiochemistryMedicineAlternative medicinePsychologySocial psychologyMolecular spectroscopy and chiralityAnalytical Chemistry and ChromatographyNMR spectroscopy and applications