Direct synthesis of novel quinoxaline derivatives <i>via</i> palladium-catalyzed reductive annulation of catechols and nitroarylamines
Feng Xie, Yibiao Li, Xiuwen Chen, Lu Chen, Zhongzhi Zhu, Bin Li, Yubing Huang, Kun Zhang, Min Zhang
Abstract
Here, a palladium-catalyzed new hydrogenative annulation reaction of catechols and nitroarylamines, allowing straightforward access to two classes of novel quinoxaline derivatives, is reported. The reaction proceeds with operational simplicity, an easily available catalyst system, and a broad substrate scope, and without the need for pre-functionalization, which offers the potential for further design of new reductive transformations of renewable resources into value-added products.
Topics & Concepts
QuinoxalineAnnulationPalladiumCombinatorial chemistryCatalysisChemistrySubstrate (aquarium)Organic chemistryGeologyOceanographySynthesis and Biological EvaluationQuinazolinone synthesis and applicationsMulticomponent Synthesis of Heterocycles